Biorepository planning starts with an assessment of the future use of samples and data collected. Variables to consider include whether the repository is designed to support a hypothesis-driven project or to allow for some future research questions. Given the longitudinal nature of several sufferer registries, registry-based biorepositories can be used to promote a variety of research objectives.
Once the mission of the repository is determined, the developer must consider the population to be studied. Options include population cohorts (mainly used to study various health conditions), health system-based cohorts (mainly used to study predefined pathologies), or condition-based cohorts (mainly used to provide resources for research focused on individual diseases). Biorepository/tissue samples are collected with different procedures based on the condition of the individual.
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Sample collection and storage:
Inventory planning involves determining the type of sample to be accepted. To date, most repository efforts have focused on genetic disease and tumor banks, but there is increasing interest in repositories for various diseases. In addition, the type of research carried out on various diseases bypasses traditional disciplines.
For example, cancer immunology has urged traditional tumor repositories to think about obtaining immunologically based samples. The types of samples are also increasingly diverse and complex. Tissue, whole blood, DNA, RNA, serum, plasma, liquor, urine, nail clippings, hair, feces, or saliva are currently stored.
Samples can be taken according to a specific test protocol or as part of clinical care. As part of a hypothesis-based study, such as sample collection for the registration of a particular patient, records of admission, processing, and storage are maintained by the investigator using the sample in the study.